参考文献 Kassebaum NJ, Bernabe E, Dahiya M, et al. Global Burden of Severe Periontitis in 1990-2010: A Systematic Review and Meta-regression. J Dent Res, 2014, 93: 1045-1053. Linden GJ, Herzberg MC. Periodontitis and systemic disease: a record of discussion of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Disease. J Periodontol, 2013, 40: 20-23. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol, 2015,15:30-44.